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The fin ray is primarily made of bone, but it also includes a diverse set of other cell types, including fibroblasts, blood vessels, nerves, and pigment cells.
Like the salamander limb, upon amputation the zebrafish fin rays first close the wound with epidermal cells that form an apical epidermal cap, and most tissue types undergo dedifferentiation, proliferation, and distal migration to establish a blastema (Knopf et al. 2011; Stewart and Stankunas 2012).
FIGURE 22.23 Zebrafish fin ray regeneration.
The magnified view of the caudal fin depicts the fin ray bones, inter-ray membranes, and regenerated tissues (blastema)
(8,C) Schematic of a longitudinal section of a single regenerated fin ray.
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